Comparison of height SDS represented as a trend line (moving average) in untreated (blue dotted line) or treated children (blue solid) with IGF1R mutations (IGF1RM) and treated children born Small for Gestational Age (SGA control, black dotted line) over age. Height SDS in the interval of 0.5 (± 0.249) years was used to calculate a median growth profile of each group.